With its standard Toyota Safety Sense 3.0 with Pre-Collision, the Toyota Prius Prime is better at preventing collisions with pedestrians than the Hyundai Ioniq 5, according to the Insurance Institute for Highway Safety:
| 
 | Prius Prime | Ioniq 5 | 
| Overall Evaluation | GOOD | ACCEPTABLE | 
| 
 | Crossing Child - DAY | |
| 12 MPH | AVOIDED | AVOIDED | 
| 25 MPH | AVOIDED | -22 MPH | 
| 
 | Crossing Adult - NIGHT | |
| 12 MPH Brights | AVOIDED | AVOIDED | 
| 12 MPH Low beams | AVOIDED | AVOIDED | 
| 25 MPH Brights | AVOIDED | -20 MPH | 
| 25 MPH Low beams | AVOIDED | -3 MPH | 
| 
 | Parallel Adult - NIGHT | |
| 25 MPH Brights | AVOIDED | AVOIDED | 
| 25 MPH Low beams | AVOIDED | AVOIDED | 
| 37 MPH Brights | AVOIDED | AVOIDED | 
| Warning Issued-Brights | 2 sec | 1.8 sec | 
| Warning Issued-Low beams | 1.9 sec | 1.5 sec | 
The Prius Prime has a standard Secondary Collision Brake, which automatically applies the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The Ioniq 5 doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
Both the Prius Prime and the Ioniq 5 have standard driver and passenger frontal airbags, front and rear side-impact airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras, rear cross-path warning, driver alert monitors and available around view monitors.

