With its standard Pre-Collision System with Pedestrian Detection, the Toyota Rav4 Prime is better at preventing collisions with pedestrians than the Honda CR-V, according to the Insurance Institute for Highway Safety:
| 
 | Rav4 Prime | CR-V | 
| Overall Evaluation | GOOD | ACCEPTABLE | 
| 
 | Crossing Child - DAY | |
| 12 MPH | AVOIDED | -10 MPH | 
| 25 MPH | -21 MPH | -18 MPH | 
| 
 | Crossing Adult - NIGHT | |
| 12 MPH Brights | AVOIDED | AVOIDED | 
| 12 MPH Low beams | AVOIDED | No Slowing | 
| 25 MPH Brights | AVOIDED | AVOIDED | 
| 25 MPH Low beams | AVOIDED | -17 MPH | 
| 
 | Parallel Adult - NIGHT | |
| 25 MPH Brights | AVOIDED | AVOIDED | 
| 25 MPH Low beams | AVOIDED | No Slowing | 
| 37 MPH Brights | AVOIDED | -33 MPH | 
| 37 MPH Low beams | -20 MPH | No Slowing | 
| Warning Issued-Low beams | 1 sec | No Warning | 
The Rav4 Prime has a standard Secondary Collision Brake, which automatically applies the brakes in the event of a crash to help prevent secondary collisions and prevent further injuries. The CR-V doesn’t offer a post collision braking system: in the event of a collision that triggers the airbags, more collisions are possible without the protection of airbags that may have already deployed.
To provide maximum traction and stability on all roads, All-Wheel Drive is standard on the Rav4 Prime. But it costs extra on the CR-V.
The Rav4 Prime XSE offers an optional Bird’s Eye View Camera to allow the driver to see objects all around the vehicle on a screen. The CR-V only offers a rear monitor and front and rear parking sensors that beep or flash a light. That doesn’t help with obstacles to the sides.
To help make backing out of a parking space safer, the Rav4 Prime has standard Rear Cross Traffic Alert and optional Parking Support Brake on the XSE automatically engages the brakes to help avoid a collision. Honda charges extra for Cross Traffic Monitor on the CR-V and its not available on the LX and the CR-V’s Cross Traffic Monitor does not include automatic braking.
Both the Rav4 Prime and the CR-V have standard driver and passenger frontal airbags, front side-impact airbags, driver knee airbags, side-impact head airbags, front and rear seatbelt pretensioners, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems and rearview cameras.

